Plasmodium, the malaria causing parasite, like all eukariots, regulates the expression of its genes by many forms, including chromatin organization. In this species, the spatial organization of chromatin seems to be regulated in clinically-relevant ways.
This project pursues these observations to build models of chromatin in blood-stage Plasmodium falciparum. The goal is to relate observations of chromatin state and organization to gene expression. In particular, I am imaging different chromatin marks using fluorescence microscopy in different time points.